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Thyronamines— The Missing Link in the Mystery of CFS and dysautonomia

“Whether or not you can observe a thing depends upon the theory you use. It is the theory which decides what can be observed.”     –Albert Einstein

According to the review by S. Piehl  et al published in Endocrine reviews journal in 2009 and titled “Thyronamines: Past, Present and Future
Intraperitoneal or central injection of 3-T1AM or T0AM into mice, rats, or Djungarian hamsters caused various prompt effects, such as metabolic depression, hypothermia, negative chronotropy, negative inotropy, hyperglycemia, reduction of the respiratory quotient, ketonuria, and reduction of fat mass.

From here on, we can hypothesize that if imbalance in the action of T1AM and T3 was applied to the dysautonomic spectrum disorders, it would create two extreme states: in the one on the left, the nervous system is overstimulated because T3 hormone, while seemingly in the normal range is not balanced out by the metabolic effects of T1AM which presents as a condition known as “hyperadrenergic POTS” and “adrenal fatigue” as it is known in alternative circles). These people are “tired but wired”, often in a truly unbearable way. On the other end of this spectrum, there is a state where the opposite effect is true: despite normal thyroid levels, the central nervous system is actually underpowered because despite falling in the normal range for the average population, the patient is not producing enough T3 to compensate of the strong “hibernating” effect induced by T1AM. These patients can hardly focus and feel like sleeping all day long.


These states are different from classic T3 hypothyroidism or hyperthyroidism where T1AM levels are appropriately decreased or increased and are able to compensate. This affects general metabolism but doesn’t have the devastating effect on the nervous system caused by T3/T1AM imbalance.

Fibromyalgia, and atypical depression (which isn’t a true depression but an altered stated of brain metabolism) fall more toward the middle of the spectrum, with fibromyalgia being more toward the left and atypical depression more on the right.

I suspect that Bipolar 2 depression and hypomania represent balanced changes in absolute values of T3/T1AM or in other words, mild shifts between hyper- and hypo- thyroidism that are exacerbated by the TAAR1 abnormality within the brain.

Multiple chemical sensitivity is likely to involve abnormality of other TAAR receptors that are involved in olfaction (sense of smell) and psychological/behavioral response to volatile trace amines.

The reason I know that this kind of spectrum exists is because I’ve been bouncing all over it for years. I also heard from enough ME/CFS patients on patient forums to know that I’m not alone in that. People describe a supplement or a drug that seems to improve their energy but they can’t tolerate it because it makes them “tired but wired” or depressed. Our inner landscapes are always changing, the cycling nature of our moods and energy states tells us that what we are dealing with is an intricate, fluctuating, and very delicate mechanism. At first glance, it may appear baffling and unpredictable but the more you get to know it, the more you realize that as maddeningly shape shifting this beast it, it does play by a certain set of rules. And if we figure out the rules of this game, we can manage it, and even eventually fully conquer it.

Most people are familiar with norepinephrine . Lately, a lot more people out there have been realizing the importance of histamine in chronic disease. But in this day and age, if we really want order to understand the true nature of this illness , we also need to talk about the receptors that are involved in the constantly unfolding epic battle of these neurotransmitters we need to talk about two largely ignored receptors that modulate their signaling: TAAR and H3. READ NEXT CHAPTER

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